Protein quality control in the secretory pathway
نویسندگان
چکیده
منابع مشابه
Protein quality control in the early secretory pathway.
Eukaryotic cells are able to discriminate between native and non-native polypeptides, selectively transporting the former to their final destinations. Secretory proteins are scrutinized at the endoplasmic reticulum (ER)-Golgi interface. Recent findings reveal novel features of the underlying molecular mechanisms, with several chaperone networks cooperating in assisting the maturation of complex...
متن کاملSecretory protein biogenesis and traffic in the early secretory pathway.
The secretory pathway is responsible for the synthesis, folding, and delivery of a diverse array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum (ER), which is charged with the tasks of correctly integrating nascent proteins and ensuring correct post-translational modification and folding. Once ready for forward traffic, proteins are captured into ER-derive...
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Green fluorescent protein (GFP) has undergone a long history of optimization to become one of the most popular proteins in all of cell biology. It is thermally and chemically robust and produces a pronounced fluorescent phenotype when expressed in cells of all types. Recently, a superfolder GFP was engineered with increased resistance to denaturation and improved folding kinetics. Here we repor...
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The endoplasmic reticulum (ER) provides a folding environment for newly synthesized secretory and membrane proteins (Ellgaard and Helenius, 2003). Secretory proteins are synthesized by ribosomes and translocated cotranslationally or posttranslationally to the ER. These newly synthesized proteins interact with ER molecular chaperones, such as immunoglobulin heavy chain-binding protein (BiP), cal...
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OBJECTIVE Loss-of-function mutations in Perk (EIF2AK3) result in permanent neonatal diabetes in humans (Wolcott-Rallison Syndrome) and mice. Previously, we found that diabetes associated with Perk deficiency resulted from insufficient proliferation of beta-cells and from defects in insulin secretion. A substantial fraction of PERK-deficient beta-cells display a highly abnormal cellular phenotyp...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2019
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201906047